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Botanical illustration of Leaf of Life
MedicinalSourced entry

Leaf of Life

Bryophyllum pinnatum

One of Jamaica's most popular bush medicines, used for colds and flu. In Switzerland, tablets made from its leaf juice have been studied for overactive bladder and sleep.

What is Leaf of Life?

Plant family
Crassulaceae, the stonecrop and jade plant family
Parts used
The leaves, often as a tea or pressed juice
Genus
Bryophyllum
Species
pinnatum

Also called

Bryophyllum

Older scientific names

Kalanchoe pinnata

Traditionally used for

  • Colds
  • Flu
  • Overactive bladder
  • Sleep
  • Period pain

Traditionally described as

  • May ease pain and inflammation (in lab tests)

Health topics

Where Leaf of Life appears in symptom search, and why. Being listed doesn't mean it's a proven treatment.

  • Colds and Nasal Congestion

    One of the plants used most often in Jamaica for colds and flu.

  • Immune Support (Colds and Flu)

    One of the plants used most often in Jamaica for colds and flu.

  • Kidney Stones

    Lab and animal studies suggest it may help dissolve kidney stones. It hasn't been tested for this in people.

  • Menstrual Discomfort

    In a small case series, 5 women with painful periods reported less pain. There are no clinical trials yet.

  • Sleep Problems (Insomnia)

    In a small study, tablets made from the leaf juice reduced night-time urination and improved sleep in women with an overactive bladder.

Traditions that use it

  • Caribbean Folk Medicine

    One of Jamaica's most popular bush medicines, used by at least 20% of people for colds and flu.

Safety

Toxicity testing

  • Leaf of life contains bufadienolides, natural compounds that can be toxic. Researchers say more work is needed to understand these compounds and make sure it's safe to use.[1]

What does the research say?

Traditional use

These are traditional uses, not proven treatments.

  • In Jamaica, leaf of life is one of the plants used most often for colds and flu. In surveys, 20% or more of people named it for these infections.[2]

  • A book based on interviews with more than 100 people in Portland and Kingston, Jamaica, includes leaf of life among the 25 most popular medicinal plants in those communities.[3]

Laboratory & animal research

Lab and animal results show what might be worth studying in people. They don't show that the herb has these effects in humans.

  • A 2024 review reported that, in lab and animal studies, it may help dissolve kidney stones and stop them forming, and may help type 2 diabetes. It also showed effects on the kidneys, liver, nerves, immune system, bacteria, parasites and cancer cells. The authors say its full medical potential and safety are still unclear.[1]

Research in people

  • In a 3-week study without a comparison group, 49 women with an overactive bladder who got up at night to urinate took tablets made from leaf of life juice. Night-time trips to the toilet fell from about 3 to about 2, and sleep improved. No serious side effects were reported.[4]

    Technical detail: Bryophyllum 50% chewable tablets, 350 mg, 2 tablets in the evening and 2 at bedtime; nocturia 3.2 ± 1.4 to 2.3 ± 1.3; improvements in ICIQ-OAB, PSQI and Epworth scores.

  • A 2023 review found lab and animal studies showing it may ease pain and inflammation and relax the womb's muscle, but no clinical trials for period pain. In a small case series, 5 women with painful periods took a leaf of life product used in Swiss obstetrics; all reported less pain, and 4 used fewer painkillers.[5]

In short

Contains bufadienolides, compounds that can be toxic; its safety needs more study.

Sources

  1. [1] Bryophyllum pinnatum (Lam.) Oken: unravelling therapeutic potential and navigating toxicity — Physiology and Molecular Biology of Plants · DOI: 10.1007/s12298-024-01509-7Peer-reviewed study
  2. [2] Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive Compounds — Molecules · DOI: 10.3390/molecules26030607Peer-reviewed study
  3. [3] Popular Medicinal Plants in Portland and Kingston, Jamaica — Springer (Advances in Economic Botany) · DOI: 10.1007/978-3-030-48927-4Peer-reviewed study
  4. [4] Bryophyllum pinnatum and Improvement of Nocturia and Sleep Quality in Women: A Multicentre, Nonrandomised Prospective Trial — Evidence-Based Complementary and Alternative Medicine · DOI: 10.1155/2023/2115335Peer-reviewed study
  5. [5] Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series — Frontiers in Pharmacology · DOI: 10.3389/fphar.2023.1292919Review or clinical trial

This information is educational and traditional in nature, and is not a substitute for professional medical advice.